G-Rich Sequences UTR DataBase
GRS_UTRdb contains information on composition and distribution of putative Quadruplex forming 'G'-Rich Sequences (QGRS) in the untranslated regions (UTRs) of eukaryotic mRNA sequences. The data stored in the GRS_UTRdb is based on computational analysis of NCBI Entrez Gene entries and their corresponding annotated nucleotide sequences of RefSeq/GenBank. Computations were performed with the help of an indigenously developed software program which is based on published algorithms for recognition and mapping of putative QGRS.
The UTRs of mRNAs contain motifs that are vital for regulation of posttranscriptional gene expression. Much attention has been paid to study the composition of regulatory RNA motifs and mechanism of their interactions with the cellular machinery. Guanine rich regions of nucleic acids that have been shown to form G-quadruplex structures have been implicated in a variety of regulatory processes in the cytoplasm. GRS_UTRdb contains computed data for occurrences of the G-quadruplex motifs, and their distribution patterns in the 5’- and 3’-UTRs of a large number of eukaryotic mRNAs. The goal of this experiment is to built a resource for exploring the role of G-quadruplex structure in regulation of gene expression at posttranscriptional level.
Kikin, O., Zappala, Z., D'Antonio, L., and Bagga, P. (2008) GRSDB2 and GRS_UTRdb: Databases of Quadruplex Forming G-rich Sequences in pre-mRNAs and mRNAs. Nucleic Acids Res. 36(suppl_1): p. D141-D148