G-Quadruplex Resource Site

The quadruplex structures formed by guanine rich nucleic acid sequences have received significant attention because of increasing evidence for their role in important biological processes and as therapeutic targets. We have generated several computational tools to predict G-quadruplexes in nucleotide sequences and map them to functionally relevant locations on mRNAs and pre-mRNAs. The G-Quadruplex Resource Site serves as a portal to our suite of software programs and databases for analysis of G-quadruplexes.

GRSDB2 is a second generation database of G-quadruplexes. Like its first version, GRSDB, it contains information on composition and distribution of putative Quadruplex-forming G-Rich Sequences (QGRS) mapped in the alternatively processed eukaryotic pre-mRNA sequences.

GRS_UTRdb contains information on composition and distribution of putative Quadruplex forming 'G'-Rich Sequences (QGRS) in the untranslated regions (UTRs) of eukaryotic mRNA sequences.

QGRS Mapper is a software program that generates information on composition and distribution of putative Quadruplex forming G-Rich Sequences (QGRS) in nucleotide sequences. It can be used for the analysis of genomic sequences, e.g. promoter and telomeric regions, as well as RNA sequences. It is also designed to handle the analysis of mammalian pre-mRNA sequences, including that are alternatively processed.

The goal of QGRS-H Predictor is to map and analyze phylogenetically conserved putative Quadruplex forming 'G'-Rich Sequences (QGRS) in the mRNAs, ncRNAs and genomic sequences like Promoter, Telomeric and gene flank regions.

Please Cite:

Frees, S., Menendez, C., Crum, M., and Bagga, P. (2014). QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs. Human Genomics. 8:8.

Menendez, C., Frees, S., and Bagga, P. (2012) QGRS-H Predictor: A Web Server for Predicting Homologous Quadruplex forming G-Rich Sequence Motifs in Nucleotide Sequences. Nucleic Acids Res. doi: 10.1093/nar/gks422. 40: W96-W103.

Kikin, O., Zappala, Z., D'Antonio, L., and Bagga, P. (2008) GRSDB2 and GRS_UTRdb: Databases of Quadruplex Forming G-rich Sequences in pre-mRNAs and mRNAs. Nucleic Acids Res. 36(suppl_1): p. D141-D148

Kikin, O., D'Antonio, L. and Bagga, P. (2006) QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences Nucleic Acids Res. 34 (Web Server issue):W676-W682.

Kostadinov, R., Malhotra, N., Viotti, M., Shine, R., D’Antonio, L., and Bagga, P.S. (2006) GRSDB: A database of quadruplex forming G-rich sequences in alternatively processed mammalian pre-mRNA sequences. Nucleic Acids Res. (Database issue). 34: D119-D124.