G-Quadruplex
  The quadruplex structures formed by guanine rich nucleic acid sequences have received significant attention because of increasing evidence for their role in important biological processes and as therapeutic targets. We have generated several computational tools to predict G-quadruplexes in nucleotide sequences and map them to functionally relevant locations on mRNAs and pre-mRNAs. The G-Quadruplex Resource Site serves as a portal to our suite of software programs and databases for analysis of G-quadruplexes.
G-quadruplex Database 2.0

GRSDB2 is a second generation database of G-quadruplexes. Like its first version, GRSDB, it contains information on composition and distribution of putative Quadruplex-forming G-Rich Sequences (QGRS) mapped in the alternatively processed eukaryotic pre-mRNA sequences.
 
G-quadruplex UTR Database

GRS_UTRdb contains information on composition and distribution of putative Quadruplex forming 'G'-Rich Sequences (QGRS) in the untranslated regions (UTRs) of eukaryotic mRNA sequences.
 
G-quadruplex Mapper

QGRS Mapper is a software program that generates information on composition and distribution of putative Quadruplex forming G-Rich Sequences (QGRS) in nucleotide sequences. It can be used for the analysis of genomic sequences, e.g. promoter and telomeric regions, as well as RNA sequences. It is also designed to handle the analysis of mammalian pre-mRNA sequences, including that are alternatively processed.

Map QGRS in a pre-mRNA
Map QGRS in an mRNA
Analyze a FASTA/Raw sequence

Map QGRS in a pre-mRNA (New Beta Version)

 

Please Cite:

  • Kikin, O., Zappala, Z., D'Antonio, L., and Bagga, P. (2008) GRSDB2 and GRS_UTRdb: Databases of Quadruplex Forming G-rich Sequences in pre-mRNAs and mRNAs. Nucleic Acids Res. 36(suppl_1): p. D141-D148
  • Kikin, O., D'Antonio, L. and Bagga, P. (2006) QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences Nucleic Acids Res. 34 (Web Server issue):W676-W682.

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