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Ramapo College Bioinformatics Group
GRSDB - The 'G'-Rich Sequences Database


NOTE
This project has been superseded by

G-quadruplex Database 2.0


GRSDB: G-Rich Sequences DataBase contains information on composition and distribution of putative Quadruplex forming 'G'-Rich Sequences (QGRS) in the alternatively processed (alternatively spliced or alternatively polyadenylated) mammalian pre-mRNA sequences. The data stored in the GRSDB is based on computational analysis of genomic nucleotide sequences obtained from fully annotated GenBank/RefSeq entries. Computations were performed with the help of an indigenously developed software program which is based on published algorithms for recognition and mapping of putative QGRS. More...

Recently, there has been a tremendous amount of interest in studying quadruplex forming G-rich sequences in the mammalian genomes. This is evident from a surge in the published literature. GRSDB provides a unique avenue for studying such sequences in the context of RNA processing sites. In addition to providing data on composition and locations of QGRS relative to the processing sites in the pre-mRNA sequence, GRSDB features visual comparison of QGRS distribution patterns among all the alternative RNA products of a gene with the help of dynamically generated graphics. More...

Please Cite:
GRSDB: a database of quadruplex forming G-rich sequences in alternatively processed mammalian pre-mRNA sequences. Rumen Kostadinov, Nishtha Malhotra, Manuel Viotti, Robert Shine, Lawrence D'Antonio and Paramjeet Bagga. Nucleic Acids Res. 2006 Jan 1;34 Database Issue: D119-D124.

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